1251 Wescoe Hall. Pharm&Tox
Malott 5060, University of Kansas, Lawrence, KS 66045
Our group studies the mechanism of action of lipid signaling mediators. Our goals are to describe enzymes, transporters and binding proteins that allow for non cell-autonomous lipid signaling.
The fundamental questions we address are:
1) how does the signal-generating cell regulate lipid hormone levels to mediate a spatially and temporally-controlled physiological process,
2) how is the lipid signal transported from cell to cell,
4) what are the enzymes and feedback mechanisms that limit the extent of lipid signaling.
Areas of research in our lab include:
- structure-function studies of enzymes involved in the metabolism of bioactive lipids
- investigation of the substrate specificity and regulation of lipid processing enzymes
- examination of the physiological role of lipid processing enzymes using transgenic animal models