Bioactive Lipids
Contact: alexmoise@ku.edu
785-864-1010
Here are some examples of our latest work:
1. Moise, A. R., Grant, J. R., Vitalis, T. Z., and Jefferies, W. A. (2002) Adenovirus E3-6.7K maintains calcium homeostasis and prevents apoptosis and arachidonic acid release, J. Virol. 76, 1578-87.
2. Moise, A. R., Grant, J. R., Lippe, R., Gabathuler, R., and Jefferies, W. A. (2004) The adenovirus E3-6.7K protein adopts diverse membrane topologies following posttranslational translocation, J. Virol. 78, 454–463.
3. Batten, M. L., Imanishi, Y., Maeda, T., Tu, D. C., Moise, A. R., Bronson, D., Possin, D., Van Gelder, R. N., Baehr, W., and Palczewski, K. (2004) Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver, J. Biol. Chem. 279, 10422-32.
4. Moise, A. R., Kuksa, V., Imanishi, Y., and Palczewski, K. (2004) Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase, J. Biol. Chem. 279, 50230-42. (cover feature)
5. Moise, A. R., Kuksa, V., Blaner, W. S., Baehr, W., and Palczewski, K. (2005) Metabolism and transactivation activity of 13,14-dihydroretinoic acid, J. Biol. Chem. 280, 27815-25.
6. Moise, A. R., von Lintig, J., and Palczewski, K. (2005) Related enzymes solve evolutionarily recurrent problems in the metabolism of carotenoids, Trends Plant. Sci. 10, 178-86.
7. Maeda, A., Maeda, T., Imanishi, Y., Golczak, M., Moise, A. R., and Palczewski, K. (2006) Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters, Biochemistry 45, 4210-9.
8. Moise, A. R., Golczak, M., Imanishi, Y., and Palczewski, K. (2007) Topology and membrane association of lecithin: retinol acyltransferase, J. Biol. Chem. 282, 2081-90.
9. Moise, A. R., Isken, A., Dominguez, M., Lera, A. R., Lintig, J. V., and Palczewski, K. (2007) Specificity of zebrafish retinol saturase: Formation of all-trans-13,14-dihydroretinol and all-trans-7,8- dihydroretinol, Biochemistry 46, 1811-1820.
10. Travis, G. H., Golczak, M., Moise, A. R., and Palczewski, K. (2007) Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents, Annu Rev Pharmacol Toxicol 47, 469-512.
11. Moise, A. R., Noy, N., Palczewski, K., and Blaner, W. S. (2007) Delivery of retinoid-based therapies to target tissues. Biochemistry 46, 4449-58 (selected as Hot Article).
12. Moise, A. R., Domínguez M, Alvarez S, Alvarez R, Schupp M, Cristancho A. G., Kiser P. D., de Lera A. R., Lazar M. A., Palczewski K. (2008) Stereospecificity of retinol saturase: absolute configuration, synthesis and biological evaluation of dihydroretinoids. J. Am. Chem. Soc. 130, 1154-5.
13. Moise, A. R. Alvarez S., Dominguez M., Alvarez R., Golczak M., Lobo G. P., von Lintig J, de Lera A. R., Palczewski K. (2009) Activation of retinoic acid receptors by dihydroretinoids. Mol. Pharmacol. 76:1228-37
14. Moise, A. R., Lobo G. P., Erokwu B., Wilson D. L., Peck D., Alvarez S., Domínguez M., Alvarez R., Flask C. A., de Lera A. R., von Lintig J., Palczewski K. (2010) Increased adiposity in the retinol saturase knockout mouse. FASEB J. 24:1261-70
15. Lobo G. P., Hessel S., Eichinger A., Zongaro S., Noy N, Moise A. R., Wyss A., Palczewski K., von Lintig J. ISX is a retinoic acid sensitive gatekeeper that controls intestinal beta-carotene absorption and vitamin A production. (2010) FASEB J. 24:1656-66
16. Moise, A.R. Pharmacology of Retinoid Receptors. (2011) TOCRIS Bioscience-Scientific Reviews pdf
17. Pang X. Y., Cao J., Addington L., Lovell S., Battaile K. P., Zhang N., Rao J. L., Dennis E. A., Moise A. R. Structure/Function Relationships of Adipose Phospholipase A2 Containing a Cys-His-His Catalytic Triad. (2012) J. Biol. Chem. 2012 287:35260-74
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