We are seeking highly motivated individuals to fill in Research Associate and Postdoctoral positions in the laboratory of Dr. Alex Moise to research the following areas:
A) Structure-function studies of proteins involved in lipid metabolism or lipid signaling
B) Studies of lipid signaling mechanisms and the physiological role of enzymes involved in the metabolism of bioactive lipids
Job location is the Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas. The positions are funded by NIH. The laboratory is well equipped to study lipid signaling, analyze cell and animal models and to conduct protein expression and purification. Our funding and project is part of the COBRE Center in Protein Structure and Function http://psf.cobre.ku.edu/ which in addition to oversight provides core services and equipment including X-ray generator, 800 and 600 MHz NMR instruments, Biacore for label free studies. The KU campus also hosts a High Throughput Screening Laboratory, a Center for Bioinfomatics and a Mass Spectrometry facility. In addition, we have regular access to synchrotron radiation beamlines.
Successful candidates must have a recent Ph.D. in biochemistry or a related field with a strong background in either:
A) purification and characterization of proteins, and protein-ligand complexes, investigation of enzyme mechanism. A background in membrane protein purification or purification of lipid processing enzymes is preferred.
B) analysis of lipid metabolism and lipid hormone signaling pathways using cell culture and animal models, experience in lipid metabolite analysis by TLC, HPLC, LC- or GC-MS, detailed knowledge of the activity and metabolism of lipid signaling mediators
In 2011, KU School of Pharmacy ranked fourth in the nation among Schools of Pharmacy in the amount of National Institutes of Health funding; 2011 is the 10th consecutive year the school has been ranked in the top five receiving more than $18,400,000 in NIH research funding in fiscal year 2010. The KU School of Pharmacy is situated in Lawrence Kansas, which was named one of the top 10 US college towns. Lawrence boasts a vibrant downtown, youthful attitude - nearly 50% of residents are younger than 24 years of age - and a multitude of outdoor activities at Clinton Lake, the Kansas River and the city’s 50 parks. Kansas City, 41 miles east of Lawrence, is a major US city with a variety of renowned museums, athletic venues, dining and cultural institutions.